The optimal effect-site concentration of remifentanil to attenuate the pain caused by propofol
نویسندگان
چکیده
BACKGROUND The injection pain of propofol is a frequent and well-known adverse effect. This study was designed to determine the optimal effect-site concentration of remifentanil for minimizing injection pain during induction with propofol. METHODS A total intravenous anesthetic technique was used for patients undergoing general anesthesia and remifentanil was pretreated to reach a certain target concentration before propofol injection. Using Dixon's up-and-down method, the degree of pain described by the patient was used to adjust the target concentration of remifentanil for the next patient. Ten success-failure curves (crossovers) were sought to find the effect-site concentration (EC) of remifentanil for minimizing injection pain of propofol. RESULTS The EC of remifentanil in 50% and 95% of adult female population (EC(50) and EC(95)) for minimizing injection pain of propofol were 3.09 ng/ml (95% confidence limits [CI] 2.92-3.30 ng/ml) and 3.78 ng/ml (95% CI 3.45-3.95 ng/ml), respectively. Clinically significant hemodynamic compromise or respiratory complications were not found during remifentanil infusion. CONCLUSIONS Maintaining 3.78 ng/ml EC of remifentanil during induction with propofol attenuate propofol injection pain without serious adverse events in female patients undergoing general anesthesia and this method may provide the patient's comfort without preparing other drugs for pain relief.
منابع مشابه
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Remifentanil is an ultra short acting opioid that is suitable for many operations and is wildly used for induction and maintenance of anesthesia. In this article we have reported the incidence of abdominal pain after cataract surgery in patients with remifentanil based anesthesia. This study is a randomized single blind clinical trial on 300 patients who were candidates for elective cataract su...
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Received: January 6, 2009. Accepted: February 27, 2009. Corresponding author: Sang Tae Kim, M.D., Department of Anesthesiology and Pain Medicine, College of Medicine, Chungbuk National University, Gaeshin-dong, Heungdeok-gu, Cheongju 361-711, Korea. Tel: 82-43-269-6237, Fax: 82-43-272-0264, E-mail: [email protected] Copyright c Korean Society of Anesthesiologists, 2009 What is the optimal ef...
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BACKGROUND Propofol injection pain is an unpleasant experience to patients and its prevalence can be influenced by age and gender. We determined the half maximal effective concentration (EC(50)) of remifentanil for preventing the microemulsion propofol injection pain in the male and female adult groups. METHODS After institutional review board approval, a total of 60 patients were assigned in...
متن کاملThe optimal effect-site concentration of remifentanil for lightwand tracheal intubation during propofol induction without muscle relaxation.
STUDY OBJECTIVE To determine the most suitable effect-site concentration of remifentanil during lightwand intubation when administered with a target-controlled infusion (TCI) of propofol at 4.0 μg/mL without neuromuscular blockade. DESIGN Prospective study using a modified Dixon's up-and-down method. SETTING Operating room of an academic hospital. PATIENTS 28 ASA physical status 1 and 2 p...
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عنوان ژورنال:
دوره 63 شماره
صفحات -
تاریخ انتشار 2012